منابع مشابه
T Cell Vaccination as a Tool in the Treatment of Collagen Induced Arthritis in Albino Rats
Background: The effectiveness of T cell vaccination has been demonstrated in a variety of animal models of both induced and spontaneous autoimmune diseases. Objective: The purpose of this study was to test the T cell vaccination protocol to treat and prevent collagen induced arthritis (CIA) in a rheumatoid arthritis model. Methods: CIA was induced by an intradermal injection of an artheritogen ...
متن کاملSynergy between adjuvant arthritis and collagen-induced arthritis in rats
Adjuvant arthritis (AA) in rats is susceptible to cell-mediated passive transfer. Collagen-induced arthritis (CIA) in rats is susceptible to passive transfer with antibody to type II collagen. We report here the development of strikingly severe arthritis in Lewis rats as the result of synergy between passively transferred antibody to type II collagen from rats with CIA and concanavalin A (Con A...
متن کاملInterleukin-19 blockade attenuates collagen-induced arthritis in rats.
OBJECTIVES RA is the most common form of inflammatory arthritis. IL-19 acts as a pro-inflammatory cytokine involved in the pathogenesis of RA. We investigated whether anti-IL-19 antibody treatment would modulate the severity of the disease in a CIA rat model. METHODS We generated a CIA model by immunizing rats with bovine type II collagen. CIA rats were s.c. treated with anti-IL-19 antibody 1...
متن کاملChronopharmacology of mizoribine in collagen-induced arthritis rats.
We previously reported that higher therapeutic effects were obtained in rheumatoid arthritis (RA) patients and RA model animals when the dosing-times of methotrexate and tacrolimus were chosen according to the 24-h rhythms of the inflammatory response. Mizoribine (MZR) is an immunosuppressive agent and is used against RA in the same manner as methotrexate and tacrolimus. In this study, we exami...
متن کاملt cell vaccination as a tool in the treatment of collagen induced arthritis in albino rats
background: the effectiveness of t cell vaccination has been demonstrated in a variety of animal models of both induced and spontaneous autoimmune diseases. objective: the purpose of this study was to test the t cell vaccination protocol to treat and prevent collagen induced arthritis (cia) in a rheumatoid arthritis model. methods: cia was induced by an intradermal injection of an artheritogen ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1979
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780220406